The Laboratory of Chromatography and Mass Spectrometry of the Jagiellonian Center of Innovation has a range of equipment dedicated to a variety of analytical tests. The Laboratory’s liquid and gas chromatographs coupled with various detectors allow the analysis of a wide range of chemical compounds: from identification to quantitative tests. We also have dedicated equipment for tests in the area of mass spectrometry, pharmacokinetics, and biochemical protein analysis.

Liquid chromatography

• UHPLC (Dionex) coupled to detectors:
  • UV-Vis DAD (190–900 nm), ELSD
  • Corona Veo RS (operating temperature range: +5^oC to +100^oC)
  • MALS (determination of mass from 100 Da to 1,250 kDa)
  • DLS
  • Q-ToF mass spectrometer (ionization sources: ESI, APCI) (range: 20 to 15,000 m/z)
  • Fluorescent FLD (range: Ex 200 to 630; Em 220 to 650)
  • Refractometric (RI) detector

Gas chromatography

• Chromatography systems (Shimadzu) with autosampler for liquid sample injection and HeadSpace attachment
• Detectors: MS detector and flame ionization detector (FID)

Supercritical CO₂ fluid chromatography (SFC)

• Analytical chromatograph (Waters) coupled to PDA detector
• Preparative chromatography system coupled with PDA and MS (single quadrupole) detector

Other equipment:

• High-resolution mass spectrometer – Impact II QTOF (Bruker) (ionization sources: ESI, APCI) (mas range: 20 to 50,000 m/z)
• Mastersizer 3000 (with Malvern Aero S; Hydro EV; Hydro Sight units)
• Suppository/globule disintegration tester (Erweka)
• Tablet disintegration time tester (Erweka)
• Tester for API release from solid dosage forms coupled to UV-Vis spectrophotometer (Erweka)
• Flow-through release tester (Erweka)
• Tester for API release from solid dosage forms (Hanson)
• Friability/abrasion tester (Erweka)
• Tablet hardness, diameter and thickness tester (Erweka)
• Suppository deformation tester (Erweka)